sugar cane extract: a treatment for atherosclerosis disease?

نویسندگان

mansour amraei dept of physiology, faculty of medicine

safoura mohamadpour dept of physiology, faculty of medicine

mohamadhesam amraei dept of physiology, faculty of medicine

چکیده

introduction: sugar cane is a giant plant of grain products. regarding the benefits of the use of medications with herbal origin, in the present study the impact of sugar cane extract on atherosclerosis and ldl-c and hdl-c in the serum of hypercholesterolemic rabbits was studied. materials and methods: 24 adult male new zealand rabbits race with an average weight of 2 kg were classified into four groups: the control group had a normal diet, sham group and the 1 , 2 experimental group were cholesteroled with 2% high cholesterol regime and received drug solvent, sugar cane extract with 3.7 and 7.4 mg/kg doses as an oral treatment per day, respectively . after eight weeks of treatment, blood were collected and subjected for measuring of ldl-c and hdl-c. for histological studies, aorta was removed and was fixed in formalin %10. spss with anova was applied for data analysis. results: the results demonstrated treatment via sugar cane extract with 3.7 and 7.4 mg/kg per day, significant reduction in ldl-c and significant increase in hdl-c, in compare with sham group, was occurred. in addition, histological examination showed that treatment by 3.7 and 7.4 mg/kg per day of sugar cane extract (the experimental groups 1, 2, respectively), prevented atheroma plaques. conclusion: sugar cane extract may be effective in reducing the amount of ldl-c and increasing hdl-c and prevents the formation of atheroma plaques.

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عنوان ژورنال:
journal of basic research in medical sciences

جلد ۱، شماره ۴، صفحات ۱-۶

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